162 PURINE NUCLETIDES SYNTHESIS DURING TERMINAL DIFFERNTIATION
نویسندگان
چکیده
منابع مشابه
Decreased Purine Synthesis during Amino Acid Starvation
Normal human lymphoblasts starved for each of several essential, but not nonessential, amino acids had decreased DNA and RNA synthesis but no change in free intracellular purine nucleotides. The rates of purine nucleotide synthesis via the de novo and salvage pathways were measured by incorporating [14C]formate and [“C]hypoxanthine labels, respectively, into lymphoblasts starved for an amino ac...
متن کاملEnzymatic synthesis of purine nucleotides.
The demonstration of a pathway of pyrimidine nucleotide synthesis in which PRPP’ is a key intermediate (1, 2) prompted a study to determine whether the same type of reaction mechanism might apply to the synthesis of purine nucleotides. In a preliminary note the condensation of adenine with PRPP to yield A5P was reported (3). Subsequent work has established the existence of enzymes in yeast whic...
متن کاملSYNTHESIS OF PURINE ACYCLONUCLEOSIDES HAVING PRONOUNCED ANTIVIRAL ACTIVITY
The synthesis of a series of purine analogues of the acyclonucleoside compound 14 (acyclovir) is described. Compounds in this series have been shown to have pronounced activity against herpes virus-type l(HSV-1). The anti-viral activities of other analogs whose syntheses were recently reported [1] by us are also described
متن کاملDe novo purine synthesis in human lymphocytes.
A partially purified enzyme extract from lectin-transformed human peripheral blood lymphocytes synthesized purine nucleotides de nouo. Although the relatively lower specific activity of the pathway compared with that in the avian liver preparation previously described (Rowe, P. B., McCairns, E., Madsen, G., Sauer, D., and Elliott, H. (1978) J. Biol. Chem. 253, 7711-7721) limited the extent of p...
متن کاملThe enzymatic synthesis of purine ribosides.
The glycosidic bond between ribose (or desoxyribose) and an imidazole nitrogen is a linkage characteristic of a number of important biological substances, particularly the nucleosides, nucleotides, and nucleic acids. Enzymes which attack the ribosidic linkage have been described by various investigators. Although a direct splitting of the ribosidic linkage of nucleotides has been reported (l), ...
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ژورنال
عنوان ژورنال: Pediatric Research
سال: 1988
ISSN: 0031-3998,1530-0447
DOI: 10.1203/00006450-198807000-00186